Key Findings

This is a quick summary of the main discovery for each research paper we have published, organized issue by issue. Each key finding is below the article title, with a link to the abstract. 


Search key findings View Previous Lists


September 2017

Life-time risk of mortality due to different levels of alcohol consumption in seven European countries: implications for low-risk drinking guidelines

If low-risk alcohol guidelines were based on an acceptable risk of one in 1000 premature deaths, maximums for Europe should be 8–10 g/day for women and 15–20 g/day for men, and some current guidelines would need downward revision.

Link to Abstract

Internet interventions for adult illicit substance users: a meta-analysis

Internet interventions can yield small but significant reduction in illicit substance use.

Link to Abstract

Hospitalizations, costs and outcomes associated with heroin and prescription opioid overdoses in the United States 2001–12

Rates and costs of US hospital admissions related to heroin and prescription opioid overdose increased substantially from 2001 to 2012.

Link to Abstract

Coping mediates the effects of cognitive-behavioral therapy for alcohol use disorder among out-patient clients in Project MATCH when dependence severity is high

Coping activities seem to be a mechanism of change in cognitive-behavioral therapy for alcohol use disorder among clients with high dependence severity, but not low dependence severity.

Link to Abstract

Risk to heroin users of polydrug use of pregabalin or gabapentin

For heroin users, the combination of opioids with gabapentin or pregabalin potentially increases the risk of acute overdose death.

Link to Abstract

Insular and cingulate attenuation during decision making is associated with future transition to stimulant use disorder

People who transition from stimulant use to stimulant use disorder appear to show specific types of neural activity that may constitute a high-risk addiction profile.

Link to Abstract

Associations between childhood maltreatment and non-medical use of prescription drugs among Chinese adolescents

Maltreatment while a child is associated with an increased risk of non-medical use of prescription drugs among Chinese adolescents.

Link to Abstract

The economic burden of neonatal abstinence syndrome in the United States

The number of US hospital admissions involving neonatal abstinence syndrome increased more than fourfold between 2003 and 2012. In 2012, neonatal abstinence syndrome cost nearly $316 million.

Link to Abstract

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation: a randomized controlled trial

There appears to be no difference in smoking cessation effectiveness between 1 mg and 0.5 mg varenicline, both administered twice daily for 8 weeks.

Link to Abstract

The role of novelty seeking as a predictor of substance use disorder outcomes in early adulthood

The association between high novelty seeking and substance use disorders is not explained by common underlying individual factors and environmental exposures; thus, novelty seeking may play a causal role in the development of substance use disorders.

Link to Abstract

Electronic cigarettes, quit attempts and smoking cessation: a 6-month follow-up

Among people who smoke, those also using an e-cigarette regularly are more likely to try to quit smoking and reduce their cigarette consumption during the next 6 months.

Link to Abstract

Pharmacokinetics of concentrated naloxone nasal spray over first 30 minutes post-dosing: analysis of suitability for opioid overdose reversal

Concentrated naloxone nasal spray has a promising pharmacokinetic profile, with substantial bioavailability. Its early absorption time-course suggests it is suitable for emergency administration in the community.

Link to Abstract

Prescription contraception use and adherence by women with substance use disorders

Women with substance use disorders are less likely to use prescription contraceptives but not less likely to adhere to them once prescribed.

Link to Abstract

Significant reductions in alcohol use after hepatitis C treatment: results from the ANRS CO13-HEPAVIH cohort

Hepatitis C virus (HCV) treatment appears to help HIV–HCV co-infected patients reduce alcohol use.

Link to Abstract

Introduction of a new instrument to measure motivation for gaming: the electronic gaming motives questionnaire

The four-dimensional Electronic Gaming Motives Questionnaire is a valid instrument for measuring motives for gaming.

Link to Abstract