Key Findings

This is a quick summary of the main discovery for each research paper we have published, organized issue by issue. Each key finding is below the article title, with a link to the abstract. 


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July 2017

The safety and efficacy of baclofen to reduce alcohol use in veterans with chronic hepatitis C: a randomized controlled trial

Baclofen administered at 30 mg/day does not appear to be superior to placebo in increasing abstinence or in reducing alcohol use, cravings for alcohol or anxiety among people with alcohol use disorder.

Link to Abstract

Modifiable parenting factors associated with adolescent alcohol misuse: a systematic review and meta-analysis of longitudinal studies

Risk of adolescent alcohol misuse is positively associated with parental provision of alcohol, favourable parental attitudes towards alcohol use and parental drinking and is negatively associated with parental monitoring, parent–child relationship quality, parental support and parental involvement.

Link to Abstract

Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence

A greater degree of familial alcoholism is associated with a steeper decline in impulsive choice among adolescents who do not drink. More life-time drinks during adolescence is associated with increases in impulsive choice.

Link to Abstract

Trajectories of risky drinking around the time of statutory retirement: a longitudinal latent class analysis

In Finland, approximately 12% of people who reach retirement age experience a temporary increase in alcohol consumption to risky levels, while approximately 7% experience a slow decline in risky levels of alcohol consumption.

Link to Abstract

Volatility and change in chronic pain severity predict outcomes of treatment for prescription opioid addiction

Adults with chronic pain receiving out-patient treatment with buprenorphine-naloxone (BUP–NLX) for prescription opioid addiction have an elevated risk for opioid use when tapering off maintenance treatment.

Link to Abstract

Substance use disorders and the risk of suicide mortality among men and women in the US Veterans Health Administration

Among people receiving Veterans Health Administration care in the US, current substance use disorders (SUDs) signal increased suicide risk, especially among women.

Link to Abstract

Working memory ability and early drug use progression as predictors of adolescent substance use disorders

Adolescents with weak working memory have less control over impulsive urges, placing them at risk for later substance use disorder.

Link to Abstract

Generalizability of findings from randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network

The findings of randomized controlled trials (RCTs) for substance use disorder treatment do not appear to be generalizable to target populations when the RCT samples do not reflect the target populations and there is treatment effect heterogeneity across patient subgroups.

Link to Abstract

The impact of TV mass media campaigns on calls to a National Quitline and the use of prescribed nicotine replacement therapy: a structural vector autoregression analysis

Tobacco control television mass media campaigns broadcast in Scotland between 2003 and 2012 were effective in triggering calls to Smokeline (a national telephone support service for quitting smoking) but did not significantly increase the use of prescribed nicotine replacement therapy by adult smokers.

Link to Abstract

Large multi-centre pilot randomized controlled trial testing a low-cost, tailored, self-help smoking cessation text message intervention for pregnant smokers (MiQuit)

A text-messaging programme may increase cessation rates in pregnant smokers when provided alongside routine NHS cessation care.

Link to Abstract

Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial

A midazolam-droperidol combination appears to provide more rapid sedation of patients with methamphetamine-related acute agitation than droperidol or olanzapine alone.

Link to Abstract

Associations between substance use disorders and suicide or suicide attempts in people with mental illness: a Danish nation-wide, prospective, register-based study [...]

Substance use disorders are strongly associated with risk of suicide and suicide attempts in people with severe mental illness.

Link to Abstract

Treatment and primary prevention in people who inject drugs for chronic hepatitis C infection: is elimination possible in a high-prevalence setting?

Based on theoretical model projections, chronic hepatitis C in Greece could be eliminated in the next 4–5 years by increasing treatment to more than 16% of people who inject drugs per year combined with moderate increases in harm reduction coverage.

Link to Abstract

Adjustment for survey non-representativeness using record-linkage: refined estimates of alcohol consumption by deprivation in Scotland

Using information from data linkage to adjust for non-response bias in health surveys can improve estimates of alternative harmful behaviours.

Link to Abstract

Modelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland

Incarceration and the elevated transmission risk following prison release can contribute significantly to hepatitis C virus transmission among people who inject drugs.

Link to Abstract